Andrographis paniculata, The Herbal Medicine Stops Plaques Accumulated in Neurons and Production of Inmature Neurons That Cause Alzheimer's disease, Scientists Say

Kyle J. Norton, Master of Nutrition 

Herbal Andrographolide may process a neural protective effect in prevention of early onset of Alzheimer’s disease, a common type of dementia, a study suggested.

Alzheimer’s disease (AD) is a chronic neuro degenerative disease that is irreversible and starts slowly and worsens over time, affecting patients thinking ability and memory, correlated with major reductions of neurons to the respective target areas. The disease is named after German physician Alois Alzheimer.

Some researchers suggested that the disease is caused by prolonged period of plaques excessive accumulation in the brain cells,  leading to brain cells degeneration and death.

People with Alzheimer’s disease may experience the decline of cognitive and functional abilities, change of motions and moods and behavior, particularly, in reducing quality of life due to disability in physical activity.

According to the statistic provided by the Alzheimer.Net, approximately, 44 million people have Alzheimer’s or a related dementia worldwide. The disease is most common in the North America and Western Europe.

 Alzheimer’s disease is the 6th leading cause of death in the United States.

In US, Alzheimer’s cost the United States taxpayer $259 billion in 2017.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic in treating common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,….

According to the joint study lead by the Pontificia Universidad Catolica de Chile, oral administrated natural product (Andrographolide, ANDRO) isolated from Andrographis paniculata in species Octodon degus (degu) exhibited the recovery of spatial memory and learning performance, through regulated phosphorylated tau protein and amyloid beta aggregate maturation in cell survival in inducing Alzheimer’s disease.

Dr., the lead author in the joint study said, “(Andrographolide, ANDRO) inhibited) neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD”

Additionally, Andrographolide also displayed the inhibitory activity of against forming of amyloid beta (Aβ)42 through suppression of NF-κB, a protein that  regulates cell survival and function of microglia in activated response to brain damage and immunological stimuli together with the reduction in the production of pro inflammatory cytokines.

In animal study, mice treated with Andrographolide increased neural progenitor cell proliferation and decreased the number of immature neurons in the hippocampus, in compared to age-matched control mice.

Moreover, ANDRO increased the number of newborn dentate granule neurons in various parts of the brain.

The study also found that the efficacy that reduces symptoms and protects against the early onset of AD is the results of the stimulation of neurogenesis in the hippocampus.

Taking together, Andrographis paniculata is surely consisted as a therapeutic potential to protect the development of Alzheimer’s disease through various mechanisms, however, intake of large amount daily should be taken with care.

However, additional data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Andrographis paniculata anti Alzheimer’s disease possibilities.

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer’s disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.(PubMed)