#### Green Tea and Its Bioactive Epigallocatechin-3-gallate (EGCG) That Gobble Up Herpesvirus

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in inhibited herpesvirus, some scientists suggested.

Herpesvirus is a large family of DNA viruses that cause  diseases depeding to types of viral infection.

According to viral classification, there are 8 types of herpesvirus, including human herpes virus 1 that causes cold sores around the mouth. and 2 that causes genital herpes, herpes zoster that causes chickenpox and shingles, Epstein-Barr virus that causes infectious mononucleosis, cytomegalovirus (CMV) that causes mononucleosis, Human herpes virus 6 and 7(HHV6 – 7) that causes roseola and Human herpes virus 8 (HHV8) that causes cancer, such as Kaposi’s Sarcoma.
According to statistic, in United States half of teens and adults under age 50 are still infected with the oral herpes virus, and about 1 in 8 have an infection with the genital herpes virus.

All herpesviruses like other virus are nuclear-replicating, infecting healthy cells nucleus through replication of viral DNA and transcription of viral mRNA.

People infected by may experience symptoms.of painful sores in the genital area, anus, buttocks, thighs, itching, painful urination, vaginal discharge,….. and tender lumps in the groin.
However, some people may not show any symptoms at all and sometimes, the diseases may be misdiagnosed as skin condition.

Sadly, many people have blisters and sores that come back after the first herpes attack goes away.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In the study of breen tea Epigallocatechin gallate (EGCG bioactive component against researchers found that
EGCG and other purified green tea catechins as topical agents inactivates multiple clinical isolates of HSV-1 and HSV-2(1). 

Application of EGCG in 10 to 20 min and reduced HSV-1 titers by the same amount in 30 to 40 min reduced HSV-2 titers by ≥1,000-fold(1).

Dr. Charles E, the lead scientists said, “(The efficacy in ameliorated risk of HSV), because EGCG would be able to directly inactivate extracellular HSV virions in the vaginal lumen” and ” At a concentration range that can easily be delivered to the female reproductive tract”.

Interestingly, in study of Epigallocatechin-3-gallate (EGCG) effects on primary effusion lymphoma (PEL), an aggressive neoplasm caused by human herpesvirus 8 (HHV8), researchers found that EGCG inhibits induced cell death and ROS generation in PEL cells in a dose-dependent manner(2).
Furthermore, application of EGCG reduced the production of progeny virus from PEL cells without causing HHV8 reactivation(2). 

These results suggest that EGCG may have a therapeutic treatment of HHV8 infection and HHV8 that cause lymphomas.
Most importantly, according to the joint study conducted by the Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, epigallocatechin-3-gallate (EGCG), processed significant anti-infective properties. EGCG exerted different modes of action in inhibited the diverse families of viruses(3)
In details(3), EGCG 

* inhibited HCV through viral entry by interference with binding to target cells.
* Inhibited integrase, an enzyme produced by a retrovirus HCV by binding to envelope and CD4 and interference.
* Reduced HBV antigen expression, extracellular HBV DNA and cccDNA
* Induced damage and inactivation of virions of HSV-1/HSV-2, probably by binding to envelope proteins
* Inhibited EBV transcription of immediate-early genes Rta, Zta and EA-D
* Inactivated Adenovirus particles, inhibited Adenovirus intracellular virus growth and viral protease
* Alternated influenza virus physical integrity of virus particles, inhibited entry by binding to haemagglutinin
* Suppressed enterovirus replication via modulation of cellular redox milieu

Taking altogether, green tea and its bioactive constituents may be used  in combined with conventional medicine for prevention and treatment of herpesvirus. 
However, further data collection on large example size and multi centers studies performed with human consumption of the green tea and its bioactive polyphenol epigallocatechin 3-gallate (EGCG), during the course of herpesviral infection will be necessary to complete the picture of their anti herpesviral possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus by Charles E. Isaacs, Guang Y. Wen, Weimin Xu, Jun Hua Jia, Lisa Rohan, Christopher Corbo, Vincenzo Di Maggio, Edmund C. Jenkins, Jr., Sharon Hillier(PubMed)
(2) Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells by Tsai CY1, Chen CY2, Chiou YH3, Shyu HW4, Lin KH5, Chou MC6, Huang MH7, Wang YF(PubMed)
(3) Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea by Steinmann J1, Buer J, Pietschmann T, Steinmann E(PubMed)